Vitamin E as DeltaGold® tocotrienols

Vitamin E is a powerful, essential nutrient in the human diet. Without this potent fat-soluble antioxidant, the human reproductive cycle comes to a halt. The term “Vitamin E” covers eight compounds grouped into tocopherols and tocotrienols, each with different chemistries and biological effects. Although the benefits of vitamin E have been well documented over the last century, research efforts have focused primarily on one half of this common antioxidant family - the alpha-tocopherol. Despite this vast scope of research, newer studies have shown that alpha-tocopherol fails to be the most powerful form of the nutrient. Instead, researchers have shifted toward studying the tocotrienol form, which expresses a more versatile reactivity with improved benefits. It has been from this exciting new perspective that DeltaGold® was formed – with the intention to improve the benefits of vitamin E supplements by shifting the current paradigm of vitamin E therapy to focus instead on the impressive potential of tocotrienols.

Cardiovascular health*

DeltaGold® supports healthy blood lipid metabolism and a healthy inflammatory response. ¹ 

Bone health*

Tocotrienols have been studied in a human clinical trial of post-menopausal osteopenia subjects, and reductions in bone loss were observed. ³

Metabolic health*

In a study on patients with NAFLD, researchers found a 15% decrease in biomarkers for liver damage associated with the disease through tocotrienol supplementation. ¹ ² Reduction in fat and enzymes, as well as inflammation in the liver were observed.

Skin health*

In studies, supplementation of tocotrienols before exposure to radiation protected mice against injury by reducing inflammation and improving the skin’s ability to regenerate. ⁴ In clinical trials, Vitamin E has been shown to improve healing from burns through the use of topical creams that penetrate easily and increase healing responses. ⁵

50x more potent

Many antioxidants exist in nature, including lycopene, CoQ10, and lutein. However, vitamin E has proven to be highly effective and uniquely equipped to penetrate and reside within the cell membrane, unlike many other water-soluble antioxidants. Aside from being 50 times more effective than tocopherols at protecting cell membranes, tocotrienols can safeguard the composition of essential fats found in foods and supplements like omega-3s⁶ ⁷. Above all, isomers, gamma- and delta-tocotrienol were found to have the greatest antioxidant properties⁸ ⁹.

Dr. Barrie Tan - the main authority behind DeltaGold®

For the last 35 years, Barrie has immersed himself in the world of Vitamin E and is considered to be one of the world’s foremost experts, credited with commercializing tocotrienol in 3 major natural sources – palm, rice, and annatto. His first discoveries were in palm & rice, but due to their high levels of tocopherol, they also lacked potency. Barrie continued his research and was soon rewarded when he found the best-in-class tocotrienol in the annatto plant!

Barrie’s relationship with annatto has spanned 20 years and multiple clinical trials across chronic diseases.

¹ Qureshi, A.A., et al., Dose-dependent modulation of lipid parameters, cytokines, and RNA by delta-tocotrienol in hypercholesterolemic subjects restricted to AHA Step-1 diet. Brit J of Med & Med Res, 2015. 6(4): p. 351-366.

² Pervez, M.A., et al., Effects of Delta-tocotrienol Supplementation on Liver Enzymes, Inflammation, Oxidative stress and Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease. Turk J Gastroenterol, 2018. 29(2): p. 170-176

³ Shen, C.L., et al., Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial. Osteoporos Int, 2018. 29(4): p. 881-891.

⁴ Ghosh, S.P., et al., Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol, 2009. 85(7): p. 598-606.

⁵ Pereira, G.G., et al., Polymeric films loaded with vitamin E and aloe vera for topical application in the treatment of burn wounds. Biomed Res Int, 2014. 2014: p. 641590.

⁶ Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free radical biology & medicine. 1991;10(5):263-275.

⁷ Zou L, Akoh CC. Antioxidant activities of annatto and palm tocotrienol-rich fractions in fish oil and structured lipid-based infant formula emulsion. Food chemistry. Feb 1 2015;168:504-511.

⁸ Palozza P, Verdecchia S, Avanzi L, et al. Comparative antioxidant activity of tocotrienols and the novel chromanyl-polyisoprenyl molecule FeAox-6 in isolated membranes and intact cells. Molecular and cellular biochemistry. Jul 2006;287(1-2):21-32.

⁹ Muller L, Theile K, Bohm V. In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma. Molecular nutrition & food research. May 2010;54(5):731- 742.